Без рубрики

An analysis of the current state of the problem of studying biomarkers of human cardiovascular ageing was carried out based on an analysis of international experience. Ageing is an inevitable, constantly progressive systemic process, which is a significant risk factor for the development of most common chronic human diseases, including cardiovascular diseases. Therefore, studying markers of early cardiovascular ageing is a logical goal for developing measures to prevent the development of cardiovascular disease and improve the quality of life and prolong active longevity

akbotabugibaeva1988

1. World Health Organization. Website. [Cited 1 October 2022]. Available from URL:https://www.who.int/ru/news-room/fact-sheets/detail/ageing-and-health.2. Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J. Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat Metab. 2020 Aug;2(8):663-672. doi: 10.1038/s42255-020-0247-0. 3.Москалев А.А., Прошкина Е.Н., Белый А.А., Соловьев И.А. Генетика старения и долголетия. Вавиловский журнал генетики и селекции. 2016;20(4):426-440. DOI 10.18699/VJ16.171 Moskalev A.A., Proshkina E.N., Belyi A.A., Solovyev I.A. Genetics of aging and longevity. Vavilovskii Zhurnal Genetiki i Selektsii =Vavilov Journal of Genetics and Breeding. 2016;20(4):426-440. DOI 10.18699/VJ16.171A.S.4. Андрей С. Б., Игорь С.Б. Постгеномная теория старения человека и научное обоснование применения маломанипулированных биомедицинских клеточных препаратов аутологичного костного мозга для антистарения, увеличения продолжительности жизни и долголетия человека. Научный обозреватель -2020-Т-8-С-116.Andrey S.B., Igor S.B. Postgenomic theory of human aging and scientific rationale for the use of low-manipulation biomedical cell preparations of autologous bone marrow for anti-aging, increasing human life expectancy and longevity. Scientific observer -2020-T-8-S-116.5.Savji N, Rockman CB, Skolnick AH, Guo Y, Adelman MA, Riles T, Berger JS. Association between advanced age and vascular disease in different arterial territories: a population database of over 3.6 million subjects. J Am Coll Cardiol. 2013 Apr 23;61(16):1736-43. doi: 10.1016/j.jacc.2013.01.054.6. Justice JN, Ferrucci L, Newman AB, Aroda VR, Bahnson JL, Divers J, Espeland MA, Marcovina S, Pollak MN, Kritchevsky SB, Barzilai N, Kuchel GA. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. Geroscience. 2018 Dec;40(5-6):419-436. doi: 10.1007/s11357-018-0042-y.7. Moreno-Villanueva M, Bürkle A. Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study. Mech Ageing Dev. 2019 Jan; 177:128-134. doi: 10.1016/j.mad.2018.06.006. 8.Hirata, T., Arai, Y., Yuasa, S., Abe, Y., Takayama, M., Sasaki, T., … Hirose, N. (2020). Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages. Nature Communications, 11(1). doi:10.1038/s41467-020-17636-0 9.lexander Bürkle, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan H.J. Hoeijmakers, Olivier Toussaint, Beatrix Grubeck-Loebenstein, Eugenio Mocchegiani, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Martijn Dollé, Michel Salmon, Peter Kristensen, Helen R. Griffiths, Claude Libert, Tilman Grune, Nicolle Breusing, Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Richard Aspinall.MARK-AGE biomarkers of ageing,Mechanisms of Ageing and Development,2015;151: 2-12.doi.org/10.1016/j.mad.2015.03.006. 10. Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study. J Am Geriatr Soc. 2016 Nov;64(11):e189-e194. doi: 10.1111/jgs.145211. Takayama M, Hirose N, Arai Y, Gondo Y, Shimizu K, Ebihara Y, Yamamura K, Nakazawa S, Inagaki H, Masui Y, Kitagawa K. Morbidity of Tokyo-area centenarians and its relationship to functional status. J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):774-82. doi: 10.1093/gerona/62.7.774. 12.Щукин Ю.В., Березин И.И., Медведева Е.А., Селезнев Е.И., Дьячков В.А., Слатова Л.Н. о значении галектина-3 как маркера и медиатора эндогенного воспаления и окислительно-нитрозилирующего стресса у больных хронической сердечной недостаточностью. Российский кардиологический журнал. 2013;(2):45-49. doi.org/10.15829/1560-4071-2013-2-45-49 Shchukin Yu.B., Berezin I.I., Medvedeva E.A., Seleznev E.I., Dyachkov V.A., Slatova L.N. Galectin-3 as a marker and mediator of endogenous inflammation and nitrosylation oxidative stress in patients with chronic heart failure. Russian Journal of Cardiology. 2013;(2):45-49. (In Russ.) doi.org/10.15829/1560-4071-2013-2-45-49 13. Yoshida Y, Nakanishi K, Daimon M, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I. Alteration of Cardiac Performance and Serum B-Type Natriuretic Peptide Level in Healthy Aging. J Am Coll Cardiol. 2019 Oct 8;74(14):1789-1800. doi: 10.1016/j.jacc.2019.07.080. 14. Tseylikman V.E., Lukin A.A. International Scientific Research Journal,.Тhe effect of oxidative stress on the human body 2022;3,206-2011(117): doi.org/10.23670/IRJ.2022.117.3.037 . Цейликман В.Е., Лукин А.А. Международный научно-исследовательский журнал. Влияние окислительного стресса на организм человека 2022;3,206-2011(117): doi.org/10.23670/IRJ.2022.117.3.037. 15. Щукин Ю.В., Березин И.И., Медведева Е.А., Селезнев Е.И., Дьячков В.А., Слатова Л.Н. о значении галектина-3 как маркера и медиатора эндогенного воспаления и окислительно-нитрозилирующего стресса у больных хронической сердечной недостаточностью. Российский кардиологический журнал. 2013;(2):45-49. doi.org/10.15829/1560-4071-2013-2-45-49 Shchukin Yu.B., Berezin I.I., Medvedeva E.A., Seleznev E.I., Dyachkov V.A., Slatova L.N. Galectin-3 as a marker and mediator of endogenous inflammation and nitrosylation oxidative stress in patients with chronic heart failure. Russian Journal of Cardiology. 2013;(2):45-49. doi.org/10.15829/1560-4071-2013-2-45-49 16. Камышникова Л.А., Ефремова О.А. Влияние коморбидности на ремоделирование и дисфункцию миокарда при сердечной недостаточности с сохранной фракцией выброса. Клиническая Медицина. 2017 год; 95(12): 1070–1076 oai: dspace.bsu.edu.ru:123456789/24160. Kamyshnikova LA, Efremova OA Impact of comorbidities on myocardial remodeling and dysfunction in heart failure with preserved ejection fraction. Klinicheskaya Meditsina. 2017; 95(12): 1070–1076 oai: dspace.bsu.edu.ru:123456789/24160 17.Полунина Е.А. Сывороточный уровень продуктов глубокого окисления белков и активность супероксиддисмутазы как маркеров оксидативного стресса у пациентов с хронической сердечной недостаточностью. Кубанский научный медицинский вестник. 2019; 26(1): 122–130. https://doi.org/10.25207/1608-6228-2019-26-1-122-130 Polunina E.A. Serum level of products of deep oxidation of proteins and activity of superoxide dismutase as markers of oxidative stress in patients with chronic heart failure. Kuban scientific medical journal. 2019; 26(1): 122–130. https://doi.org/10.25207/1608-6228-2019-26-1-122-130 18.Chen DC, Potok OA, Rifkin D, Estrella MM. Advantages, Limitations, and Clinical Considerations in Using Cystatin C to Estimate GFR. Kidney360. 2022 Aug 23;3(10):1807-1814. doi: 10.34067/KID.0003202022. 19. Moreno-Villanueva M, Bürkle A. Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study. Mech Ageing Dev. 2019 Jan; 177:128-134. doi: 10.1016/j.mad.2018.06.006. 20.Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study Bacalini, M.G., Reale, A., Malavolta, M., Ciccarone, F., Moreno-Villanueva, M., Dollé, M.E.T. Jansen, E., Grune, T., Gonos, E.S., Schön, C., Bernhardt, J., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Capri, M., Hervonen, A., Hurme, M., Slagboom, P.E., ... Zampieri, M. (2021). Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study. GeroScience, 43(3), 1283-1302. 2021.https://doi.org/10.1007/s11357-021-00347-9 21. Mito T, Takemoto M, Antoku Y, Tanaka A, Matsuo A, Hida S, Yoshitake K, Kosuga KI, Miura SI. Influence of Serum Cholinesterase Levels on Patients Suspected of Having Stable Coronary Artery Disease. Intern Med. 2021 Apr 15;60(8):1145-1150. doi: 10.2169/internalmedicine.5719-20.22.Zou J, Chen Z, Liang C, Fu Y, Wei X, Lu J, Pan M, Guo Y, Liao X, Xie H, Wu D, Li M, Liang L, Wang P, Wang Q. Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson's Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage. Aging Dis. 2018 Feb 1;9(1):51-65. doi: 10.14336/AD.2017.0416.23. Giovannini, S., Onder, G., Liperoti, R., Russo, A., Carter, C., Capoluongo, E., Pahor, M., Bernabei, R. and Landi, F. (2011), Interleukin-6, C-Reactive Protein, and Tumor Necrosis Factor-Alpha as Predictors of Mortality in Frail, Community-Living Elderly Individuals. Journal of the American Geriatrics Society, 59: 1679-1685. https://doi.org/10.1111/j.1532-5415.2011.03570.24. Vasto S, Scapagnini G, Bulati M, Candore G, Castiglia L, Colonna-Romano G, Lio D, Nuzzo D, Pellicano M, Rizzo C, Ferrara N, Caruso C. Biomarkes of aging. Front Biosci (Schol Ed). 2010 Jan 1;2(2):392-402. doi: 10.2741/s72. 25. Engelfriet PM, Jansen EH, Picavet HS, Dollé ME. Biochemical markers of aging for longitudinal studies in humans. Epidemiol Rev. 2013;35(1):132-51. doi: 10.1093/epirev/mxs011.24. Iryna Rusanova, María E. Diaz-Casado, Marisol Fernández-Ortiz, Paula Aranda-Martínez, Ana Guerra-Librero, Francisco J. García-García, Germaine Escames, Leocadio Mañas, Darío Acuña-Castroviejo, "Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans", Oxidative Medicine and Cellular Longevity, vol. 2018, Article 9 pages, 2018. https://doi.org/10.1155/2018/767185025.Chow SL, Maisel AS, Anand I, Bozkurt B, de Boer RA, Felker GM, Fonarow GC, Greenberg B, Januzzi JL Jr, Kiernan MS, Liu PP, Wang TJ, Yancy CW, Zile MR; American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology; Council on Basic Cardiovascular Sciences; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Council on Quality of Care and Outcomes Research. Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association. Circulation. 2017 May 30;135(22):e1054-e1091. doi: 10.1161/CIR.0000000000000490.26.Mourtzi, N, Charisis, S, Tsapanou, A, et al. Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework. Alzheimer's Dement. 2023; 19: 3794–3805. https://doi.org/10.1002/alz.12980