Results of the Analysis of the Efficacy and Safety of Long-Term Anticoagulant Therapy in Kazakh Nationality Patients After Open Heart Valve Surgery

• Раздел: Хирургия
• Язык: English
• Отправляемый файл статьи (документ Word)*: Results of the Analysis of the Efficacy and Safety of Long-Term Anticoagulant Therapy in Kazakh Nationality Patients After Open Heart Valve Surgery-1c6fd388
• Имя: Ualikhan
• Фамилия: Imammyrzayev
• Адрес (E-mail): ualikhan-88@mail.ru
• ORCID iD: https://orcid.org/0000-0001-8302-6879
• Организация: АО "ННЦХ им А.Н.Сызганова"
• Страна: Казахстан
• Биографическое описание:

  1) Zhanar Nurbay, MD, PhD candidate Deputy Director for Organizational and Methodological Work. Cardiac Surgery Consultant. Cardiac Surgeon at the SOE 'City Cardiological Center' in Almaty. Kazakh Medical University “KSPH”,https://orcid.org/0000-0001-5414-6871,phdnurbay@gmail.com
  2) Miyerbekov Yergali . DSci, Professor. National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan. Ergali.m1@gmail.com; https://orcid.org/0000-0002-7609-0300
  3) Rustem Tuleutayev, MD, PhD, Head of the Department of Cardiac Surgery at the JSC "Scientific Research Institute of Cardiology and Internal Medicine", Almaty, Kazakhstan.https://orcid.org/ 0000-0002-6003-3010, rustemtuleutayev@gmail.com
  4) Pashimov Marat – Chairman of the Board. JSC “Research Institute of Cardiology and Internal Diseases”, Almaty, Kazakhstan ORCID __https://orcid.org/ 0009-0004-9316-9549
  5) Imammyrzayev Ualikhan, MD, Cardiac surgeon at the National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan. https://orcid.org/0000-0001-8302-6879, ualikhan-88@mail.ru.
  6) Svyatova Gulnara Salavatovna, Doctor of Medicine, Professor, Head of the Scientific Department of the Center for Molecular Medicine, ORCID ID 0000-0001-5092-3143, Almaty, Kazakhstan; e-mail: gsvyatova1@mail.ru
  7) Murtazaliyeva Alexandra Vladimirovna, geneticist at the Center for Molecular Medicine, ORCID ID 0000-0001-9156-5944. Almaty, Kazakhstan; alexmurtazalieva@gmail.com
  8) Berezina Galina Mikhailovna, Doctor of Biological Sciences, Associate Professor, Leading Researcher, Department of Strategy and Science, Republican Medical Genetic Consultation of Joint-Stock Company “Scientific Center of Obstetrics, Gynecology and Perinatology”, ORCID ID 0000-0002-5442-4461. Almaty, Kazakhstan; e-mail: gberezina54@mail.ru
  9) Duman Yestayev, Cardiologist, student, JSC “Research Institute of Cardiology and Internal Diseases”, Almaty,https://orcid.org/ 0009-0001-6952-043х, duman_112@mail.ru

• Дополнительные авторы: Nurbay Zh., Miyerbekov E., Tuleutayev R., Pashimov M., Imammyrzayev U., Svyatova G., Murtazaliyeva A., Berezina G., Duman Yestayev
• Ключевые слова: open heart surgery, heart valve prosthetics, warfarin-related complications, mechanical prosthesis.
• Тип, метод или подход: This study is the first of its kind conducted among Kazakh patients and aims to investigate the relationship between genotype, warfarin dosage, and the frequency of hemorrhagic and thrombotic complications. This study included 310 patients of Kazakh nationality who received warfarin therapy following open-heart surgery with mechanical valve replacement between 2015 and 2020.
• Организации: 1 - SСE «City Cardiological Center», Almaty, Kazakhstan 2 - JSC «A.N. Syzganov National Scientific Center of Surgery», Almaty, Kazakhstan. 3 - JSC "Scientific Research Institute of Cardiology and Internal Medicine", Almaty, Kazakhstan. 4 - JSC «Scientific Center of Obstetrics, Gynecology and Perinatology», Almaty, Kazakhstan 5- Center for Molecular Medicine
• Литература:

  . Shehab N, Lovegrove MC, Geller AI, Rose KO, Weidle NJ, Budnitz DS. US Emergency department visits for outpatient adverse drug events, 2013–2014. JAMA. 2016;316(20):2115. doi:10.1001/ jama.2016.162012. Hindrics G, Potpara T, Dagres N, et al. ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2020. doi:10.1093/eurheartj/ehaa6123. Ruff CT. Pharmacogenetics of Warfarin Therapy. Clin Chem. 2018;64(11):1558–1559. doi:10.1373/clinchem.2017.2849274. Yang T, Zhou Y, Chen C, Lu M, Ma L, Cui Y. Genotype-guided dosing versus conventional dosing of warfarin: a meta-analysis of 15 randomized controlled trials. J Clin Pharm Ther. 2019;44 (2):197–208. doi:10.1111/jcpt.127825. Swanson KM, Zhu Y, Rojas RL, et al. Comparing outcomes and costs among warfarin-sensitive patients versus warfarin-insensitive patients using the right drug, right dose, right time: using genomic data to individualize treatment (RIGHT) 10K warfarin cohort. PLoS One. 2020;15:5. doi:10.1371/JOURNAL.PONE.02333166. Lehto M, Niiranen J, Korhonen P, et al. Quality of warfarin therapy and risk of stroke, bleeding, and mortality among patients with atrial fibrillation: results from the nationwide FinWAF registry. Pharmacoepidemiol Drug Saf. 2017;26(6):657–665. doi:10.1002/ pds.41947. Park YK, Lee MJ, Kim JH, et al. Genetic and non-genetic factors affecting the quality of anticoagulation control and vascular events in atrial fibrillation. J Stroke Cerebrovasc Dis. 2017;26(6):1383–1390. doi:10.1016/j.jstrokecerebrovasdis.2017.02.022

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