Conflict of interest: The authors declare that they have no conflicts of interest
Akkaliyev Merkhat - PhD, аssistant of the Department of Surgical Disciplines NCJSC «Semey Medical University», Abay street 103, Semey city, Republic of Kazakhstan
References:1. Mathis Grossmann. Androgen deficiency in older men. Australian Journal of General Practice. 2019; 48(7). doi: 10.31128/AJGP-01-19-48312. Forough Samipoor, Sedigheh Pakseresht, Parvaneh Rezasoltani, Mojtaba Mehrdad. The association between hypogonadism symptoms with serum testosterone, FSH and LH in men. Aging Male. 2018; 21(1):1-8. doi: 10.1080/13685538.2017.1382468.3. Ilpo T. Huhtaniemi, Frederick C.W. Wu. Ageing male (part I): Pathophysiology and diagnosis of functional hypogonadism. Best Practice & Research Clinical Endocrinology & Metabolism. 2022; 36( 4). https://doi.org/10.1016/j.beem.2022.101622.4. Osuke Komazawa, Yasuhiko Saito. Coping with Rapid Population Ageing in Asia Discussions on Long-term Care Policy and Cross-border Circulation of Care Workers. Published by: Economic Research Institute for ASEAN and East Asia (ERIA). ISBN: 978-602-5460-33-35. Sizar O, Schwartz J. Hypogonadism. 2022 Jun 27; In: StatPearls [Internet]. PMID: 30422528. 6. G. Defeudis, R. Mazzilli, D. Gianfrilli, A. Lenzi, A. M. Isidori. The CATCH checklist to investigate adult-onset hypogonadism. Andrology, 2018; 6: 665–679. doi.org/10.1111/andr.125067. Ahmed Al-Sharefi, Scott Wilkes, Channa N Jayasena and Richard Quinton. How to manage low testosterone level in men: a guide for primary care. British Journal of General Practice 2020; 70 (696): 364- 365. doi: https://doi.org/10.3399/bjgp20X7107298. Huhtaniemi Ilpo. Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment. Asian journal of andrology. 2014; 16(2): Р. 192–202 https://doi.org/10.4103/1008-682X.122336.9. Justin M Carré, Shawn N Geniole, Triana L Ortiz , Brian M Bird , Amber Videto , Pierre L Bonin. Exogenous Testosterone Rapidly Increases Aggressive Behavior in Dominant and Impulsive Men. Biol Psychiatry. 2017 Aug 15;82(4):249-256. doi: 10.1016/j.biopsych.2016.06.009.10. Natalie C Ebner , Hayley Kamin, Vanessa Diaz, Ronald A Cohen, Kai MacDonald. Hormones as "difference makers" in cognitive and socioemotional aging processes. Front Psychol. 2015 Jan 22;5:1595. doi: 10.3389/fpsyg.2014.01595.11. Ozan Bozkurt, Deniz Bolat, Omer Demir, Oktay Ucer, Ali Şahin, Burak Ozcift, Abdulkadir Pektaş, Tahir Turan, Bilal H Gümüş, Ertan Can, Ahmet Bolukbasi, Haluk Erol and Adil Esen. Erectile function and late-onset hypogonadism symptoms related to lower urinary tract symptom severity in elderly men. Asian J Androl. 2013 Nov; 15(6): 785–789. doi: 10.1038/aja.2013.4412. Indirli R, Lanzi V, Arosio M, Mantovani G, Ferrante E. The association of hypogonadism with depression and its treatments. Front Endocrinol (Lausanne). 2023 Aug 10;14:1198437. doi: 10.3389/fendo.2023.1198437.13. Şükrü Kartalcı. Testosteron ve Depresyon. Current Approaches in Psychiatry. 2010; 2( 4): 457 – 472. eISSN:1309¬0674 pISSN:1309¬065814. Tartt AN, Mariani MB, Hen R, Mann JJ, Boldrini M. Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. Mol Psychiatry. 2022; 27(6): 2689-2699. doi: 10.1038/s41380-022-01520-y.15. Xiaojun Shao, Gang Zhu. Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder. Front. Psychiatry, 13 May 2020; 11. https://doi.org/10.3389/fpsyt.2020.0038116. Qing Zhang, Anwen Shao, Zhengyan Jiang, Huitzong Tsai, Weibo Liu. The exploration of mechanisms of comorbidity between migraine and depression. J Cell Mol Med. 2019 Jul;23(7):4505-4513. doi: 10.1111/jcmm.14390.17. Benjumin Hsu, Robert G Cumming, Fiona M Blyth, Vasi Naganathan, David G Le Couteur, Markus J Seibel, Louise M Waite, David J Handelsman. The longitudinal relationship of sexual function and androgen status in older men: the Concord Health and Ageing in Men Project. J Clin Endocrinol Metab. 2015 Apr;100(4):1350-8. doi: 10.1210/jc.2014-4104.18. Oyola MG, Handa RJ. Hypothalamic–pituitary–adrenal and hypothalam- ic–pituitary–gonadal axes: sex differences in regulation of stress respon- sivity. Stress. 2017; 20 (5): 476–94. DOI: 10.1080/10253890.2017.1369523)19. Friedrich M. Depression Is the Leading Cause of Disability Around the World. JAMA. 2017;317(15):1517. doi:10.1001/jama.2017.382620. Parikesit D, Adityagama M, Atmoko W, Birowo P, Taher A, Rasyid N. Reliability and validity of the Indonesian version of the aging males’ symptoms. Med J Indones. 2021; 30 (3): 211-214. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/531421. Michael Zitzmann. Testosterone, mood, behaviour and quality of life. Andrology. 2020 Nov;8(6):1598-1605. doi: 10.1111/andr.1286722. Georg S Kranz, Wolfgang Wadsak, Ulrike Kaufmann, Markus Savli, Pia Baldinger, Gregor Gryglewski, Daniela Haeusler, Marie Spies, Markus Mitterhauser, Siegfried Kasper, Rupert Lanzenberger. High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People. Biol Psychiatry. 2015 Oct 15;78(8):525-33. doi: 10.1016/j.biopsych.2014.09.010.23. Chen Z, Shen X, Tian K, et al. Bioavailable testosterone is associated with symptoms of depression in adult men. Journal of International Medical Research. 2020;48(8). doi:10.1177/030006052094171524. Sarah J Heany, Jack van Honk, Dan J Stein, Samantha J Brooks. A quantitative and qualitative review of the effects of testosterone on the function and structure of the human social-emotional brain. Metab Brain Dis. 2016 Feb;31(1):157-67. doi: 10.1007/s11011-015-9692-y25. Indirli R, Lanzi V, Arosio M, Mantovani G, Ferrante E. The association of hypogonadism with depression and its treatments. Front Endocrinol (Lausanne). 2023 Aug 10;14:1198437. doi: 10.3389/fendo.2023.1198437. 26. Farzan Kheirkhah, Seyed Reza Hosseini, Seyyedeh Fatemeh Hosseini, Nafiseh Ghasemi, Ali Bijani, Robert G Cumming. Relationship between testosterone levels and depressive symptoms in older men in Amirkola, Iran. Caspian J Intern Med. 2014 Spring;5(2):65-70. 27.Zhongbao Chen, Xubo Shen, Kunming Tian, Yijun Liu, Shimin Xiong, Qin Yu, Lulu Dai, Yongjun Shi, Renjuan Zhang, Rong Zeng, Qiyou Wan, Chengliang Xiong, Yuanzhong Zhou. Bioavailable testosterone is associated with symptoms of depression in adult men. J Int Med Res. 2020 Aug;48(8):300060520941715. doi: 10.1177/030006052094171528. Porav-Hodade D, Gherasim RD, Kosovski IB, Voidazan TS, Crisan N, Bogdan P, Galis R, Feciche BO, Ilona MOK, Todea-Moga C. Hormones, Age, and Erectile Dysfunction: Should Routine Testing Be Part of the Initial Evaluation? Diagnostics. 2025; 15(3):294. https://doi.org/10.3390/diagnostics1503029429. Winters, S.J. SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking? Clin Diabetes Endocrinol. 2020; 6: 17. https://doi.org/10.1186/s40842-020-00106-330. Mathis Grossmann. Hypogonadism and male obesity: Focus on unresolved questions. Clin Endocrinol (Oxf). 2018 Jul;89(1):11-21. doi: 10.1111/cen.13723.31. Tchernof A., . P. Pathophysiology of human visceral obesity: an update. Physiological Reviews. 2013; 93: 359–404.32. Dimitry Francois, Ariana Mireille Levin, Eric J. Kutscher , and Babatunde Asemota. Antidepressant-Induced Sexual Side Effects: Incidence, Assessment, Clinical Implications, and Management. Psychiatr Ann. 2017;47(3):154–160. doi.org/10.3928/00485713-20170201-01